LUMICKS brings to market revolutionary dynamic single-molecule technologies that enable—for the first time—visualization of molecular interactions and acoustic manipulation of biomolecules. These breakthroughs are allowing scientists to understand and visualize complex biological processes occurring at the molecular level, providing unparalleled insights into the fundamental cause of disease and potential for drug optimization.
LUMICKS’ ready-to-use instrumentation enables the detailed investigation of DNA–protein interactions, molecular motor activity and protein folding to address different scientific questions.
Current single-molecule techniques allow scientists to achieve only partial understanding of complex biological processes. With LUMICKS’ ground-breaking optical tweezers–fluorescence microscopy, scientists are now able to visualize and measure mechanical properties of biomolecular complexes in real time, revealing the complete picture. Manipulation, force measurements and visualization of these complexes, for example DNA-protein interactions, are performed simultaneously, which allows correlation of mechanical properties to the number, location and conformational state of proteins bound to DNA.
The C-Trap is the world’s first instrument that allows simultaneous manipulation and visualization of molecular interactions in real-time. It combines high-resolution optical tweezers, confocal microscopy or STED nanoscopy with an advanced microfluidics system in a truly integrated and correlated solution.
Using LUMICKS’ C-Trap scientists are able—for the first time—simultaneously and in real-time visualize individual biomolecules and measure mechanical properties of biomolecular complexes to reveal greater detail.
Acoustic Force Spectroscopy is a new single-molecule and single-cell manipulation method capable of applying acoustic forces on hundreds of biomolecules in parallel for precise experimentation with high throughput.
Deciphering complex molecular interactions requires many independent single-molecule measurements in order to distinguish heterogeneous behaviour and rare events from intrinsic stochasticity caused by thermal fluctuations. As for cells, many measurements are required to map cellular heterogeneity within a population. With LUMICKS’ groundbreaking AFS technology, scientists are now able to probe thousands of individual particles in parallel (such as DNA, RNA, proteins and living cells), allowing statistical analysis of the mechanical properties of biological systems based on a single experiment.
The m-Trap is a purpose built ultra-high-resolution optical tweezers instrument, specifically developed to be the most affordable instrument in its class. Designed specifically for high-resolution single-molecule force spectroscopy research, the m-Trap provides ultra-high force resolution and stability, with incredible throughput & ease-of-use, all at an unprecedented price level.
The m-Trap is capable of manipulating and characterizing structural transitions and interactions of biomolecules at the Angstrom scale with ultra-high force resolution, stability & throughput.
Avidity based screening & sorting: z-Movi™ enables direct and label-free screening and sorting of thousands of cells based on their interaction to cell or protein targets.
The z-Movi™ system is a breakthrough technology for research and development of personalized therapies, including immunotherapy. It is the first platform able to directly measure the strength of interaction, or avidity, between cells with specific targets and sort cells of interest, in a high-throughput and label-free manner.